For 2007+ models with the valve mounted Tire Pressure Monitoring System (TPMS), read note below.

From AMI, manufacturer of SLIME tire sealant:

As leaders in the tire care and repair industry, Accessories Marketing, Incorporated (AMI), the manufacturers of SLiME Tire Sealant wish to address the mandate set forth in the Transportation Recall Enhancement, Accountability and Documentation (TREAD) Act, passed in the fall of 2000. In response to this mandate, the National Highway Traffic Safety Administration (NHTSA) established the Federal Motor Vehicle Safety Standard that requires the installation of Tire Pressure Monitoring Systems (TPMS) to all vehicles by September 1, 2007.

From our findings, and after significant dialog with the leading manufacturers of TPMS devices, SLiME Tire Sealant will not damage TPMS devices. We understand TPMS manufacturers have conducted extensive testing to ensure their sensors remain operational after exposure to any chemical fluids that might come into contact with the sensors. This includes after market products, such as SLiME Tire Sealant. AMI has also conducted independent testing, which supports and verifies SLiME Tire Sealant’s compatibility with TPMS devices.

Currently, there are two types of TPMS devices available: Direct and Indirect. SLiME Tire Sealant’s TPMS formulation is compatible with all TPMS systems. However, it is important to note that once installed, Slime Tire Sealant may come in contact with the sensor in a way that renders the sensor TEMPORARILY inoperable until it is properly cleaned, inspected and re-installed by a tire care professional.

Because SLiME is a water soluble flat repair treatment, it is easily removed from the tire with water. At the time the affected tire is inspected by a tire care professional, they should clean the sealant from the tire, prepare the area and repair with a Rubber Manufacturer’s Association (RMA) approved patch/plug. The TPMS device should also be cleaned off with water to remove any sealant which may have come into contact with the device. Do not use any fine objects to ream and clean the small pressure sensor opening as it may damage the electronics. After the repaired tire is replaced and inflated the TPMS system will resume operating as normal.